Table 5.

Pharmacokinetic Parameters of Nemonoxacin Following Intravenous (1 mg/kg) Administration

n=5	Parameters	Mean±S.D.
Plasma disposition	T1/2,α (min)	12.8±7.2
	T1/2,β (min)	238.6±29.5
	CL (mL/min/kg)	24.6±5.8
	Vss (mL/kg)	7101.8±1971.2
	AUC0-480 (μg.min/mL)	29.9±6.6
Biliary excretion	Ae0-480 (μg)	23.9±5.3
	AUC0-480 (μg.min/mL)	1505.6±319.6
	AUCbile/plasma	50.7±6.9

Abbreviations: T_1/2,α, half-life of alpha phase; T_1/2,β, half-life of beta phase; CL, clearance; V_ss, volume of distribution; AUC_0-480, area under curve of 0–480 min; Ae_0-480, cumulative amount excreted in bile over the 480‐min collection interval.