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Event-free rate of occurrences of left ventricular ejection fraction <50%, left ventricular ejection fraction <40%, and treatment-emergent adverse events of cardiac failure over time. For patients with <56 days between enrolment periods, events contribute based on initial dosing (left ventricular ejection fraction <50% and left ventricular ejection fraction <40% analyses). LVEF, left ventricular ejection fraction
