Figure 3.

Biomarkers measured at baseline predicting sinus rhythm at 12-month follow-up in all participants of the biomarker study, separately analysed by rhythm at baseline (atrial fibrillation at baseline or sinus rhythm at baseline) and randomized treatment group (early rhythm control or usual care), respectively, in a post hoc analysis. Of the three biomarkers identified to be predictive of sinus rhythm in the whole cohort, NT-proBNP, ANGPT2, and BMP10, all three biomarkers retained their predictive value in the subgroup of patients randomized to usual care. All three biomarkers also retained their predictive value in the subgroup of patients in atrial fibrillation during blood draw at baseline. ANGPT2, angiopoietin 2; BMP10, bone morphogenetic protein 10; NT-proBNP, N-terminal pro-B-type natriuretic peptide