Table 2.
Baseline biomarker concentrations are shown split by rhythm at 12-month follow-up (sinus rhythm or atrial fibrillation) and by randomized group (early rhythm control or usual care)
| Randomization group | Early rhythm control | Usual care | SR vs. AF 12 months | ||
|---|---|---|---|---|---|
| Rhythm at 12-month follow-up | Sinus rhythm 12-month FU | Atrial fibrillation 12-month FU | Sinus rhythm 12-month FU | Atrial fibrillation 12-month FU | P-value* |
| NT-proBNP (pg/mL) | 377 [164–859] |
750 [376–1351] |
294 [127–700] |
782 [437–1454] |
.001 |
| ANGPT2 (ng/mL) | 2.34 [1.78–3.41] |
3.45 [2.43–5.62] |
2.24 [1.7–3.09] |
3.31 [2.15–4.62] |
.001 |
| BMP10 (ng/mL) | 2.08 [1.8–2.39] |
2.21 [1.96–2.58] |
2.04 [1.79–2.34] |
2.24 [1.94–2.66] |
.010 |
| FGF23 (pg/mL) | 151 [112–209] |
179 [125–238] |
141 [108–197] |
168 [129–226] |
.429 |
| ESM1 (ng/mL) | 2.01 [1.61–2.52] |
2.17 [1.75–2.88] |
1.98 [1.57–2.52] |
2.09 [1.73–2.66] |
.218 |
| GDF15 (pg/mL) | 1304 [958–1934] |
1441 [997–2008] |
1254 [911–1782] |
1589 [1071–2347] |
.461 |
| IGFBP7 (ng/mL) | 100 [89–114] |
108 [93–126] |
98.8 [88.5–110] |
104 [94.7–119] |
.487 |
| IL-6 (pg/mL) | 2.47 [1.57–3.88] |
2.6 [1.76–4.62] |
2.37 [1.56–3.6] |
3.02 [1.98–4.65] |
.417 |
| FABP3 (ng/mL) | 31.4 [25.6–39] |
35.3 [28.3–43.4] |
30.4 [25.7–37.8] |
33.5 [28.0–42.0] |
.151 |
| D-dimer (µg/mL) | .17 [.08–.33] |
.19 [.1–.36] |
.16 [.08–.32] |
.16 [.08–.32] |
.638 |
| TnT (ng/L) | 10.6 [7.81–15.7] |
13.0 [9–17.6] |
10.3 [7.53–15.5] |
12.5 [8.68–17.7] |
.415 |
| CRP (mg/L) | 2 [.95–4.65] |
1.97 [.9–4.63] |
2.07 [.93–4.37] |
2.52 [1.12–4.87] |
.910 |
| sCr (µmol/L) | 81.3 [70–95] |
83 [72.7–94.8] |
79.5 [68.0–91.9] |
84.4 [72–97.2] |
.541 |
| CA125 (U/mL) | 11.4 [8.0–15.8] |
12.3 [8.3–17.1] |
10.8 [7.8–15.7] |
11.4 [7.96–15.9] |
.779 |
AF, atrial fibrillation; SR, sinus rhythm; FU, follow-up; ANGPT2, angiopoietin 2; BMP10, bone morphogenetic protein 10; CA125, cancer antigen 125; CRP, C-reactive protein; D-dimer, ESM1, endothelial specific molecule 1; FABP3, fatty acid binding protein 3; FGF23, fibroblast growth factor 23; GDF15, growth differentiation factor 15; IGFBP7, insulin-like growth factor binding protein 7; IL-6, interleukin-6; NT-proBNP, N-terminal pro-B-type natriuretic peptide; TnT, cardiac troponin; sCr, serum creatinine.
* P-values were calculated using mixed logistic regression model with site as random effect, adjusted for sex, age, body mass index, diastolic blood pressure, left ventricular ejection fraction. Values are shown as median [IQR].