TABLE 3.
Association results of second-generation epigenetic age acceleration in HEXA.
| Trait | OR (95% CI)/BETA (SE) | p-value | Trait | OR (95% CI)/BETA (SE) | p-value | |
|---|---|---|---|---|---|---|
| DunedinPACE | T2D | 1.14 (1.1, 1.17) | 1.70E-16 | HDL | −2.37 (0.48) | 1.08E-06 |
| Hypertension | 1.25 (1.09, 1.44) | 1.35E-03 | Triglyceride | 33.59 (4.63) | 9.36E-13 | |
| AST | 2.37 (0.71) | 9.12E-04 | hs-CRP | 0.15 (0.05) | 1.27E-03 | |
| ALT | 3.61 (0.94) | 1.21E-04 | ||||
| PCGrimAgeEAA | T2D | 1.15 (1.1, 1.19) | 2.90E-11 | HDL | −0.57 (0.64) | 3.74E-01 |
| Hypertension | 1.1 (0.99, 1.22) | 8.56E-02 | Triglyceride | 32.04 (6.18) | 2.70E-07 | |
| AST | 2.44 (0.94) | 9.39E-03 | hs-CRP | 0.07 (0.06) | 2.32E-01 | |
| ALT | 0.91 (1.24) | 4.64E-01 | ||||
| PCPhenoAgeEAA | T2D | 1.09 (1.05, 1.13) | 2.91E-06 | HDL | −1.04 (0.57) | 6.94E-02 |
| Hypertension | 1.15 (1.03, 1.29) | 1.76E-02 | Triglyceride | 15.75 (5.57) | 4.82E-03 | |
| AST | 2.4 (0.84) | 4.37E-03 | hs-CRP | 0.1 (0.05) | 6.87E-02 | |
| ALT | 3.44 (1.1) | 1.90E-03 | ||||
| ZhangY | T2D | 1.21 (1.15, 1.28) | 3.49E-12 | HDL | 1.75 (1.66) | 2.93E-01 |
| Hypertension | 1.08 (1, 1.17) | 4.54E-02 | Triglyceride | 41.83 (8.26) | 5.02E-07 | |
| AST | 2.67 (1.26) | 3.35E-02 | hs-CRP | 0.14 (0.08) | 6.91E-02 | |
| ALT | 1.75 (1.66) | 2.93E-01 | ||||
| DunedinPACE | BMI | 0.03 (0.01) | 2.50E-04 | PWI | 0.008 (0.004) | 7.34E-02 |
| WHR | 3.3 (0.53) | 8.94E-10 | Drink | 0.04 (0.05) | 4.20E-01 | |
| Income | −0.08 (0.02) | 7.23E-05 | Smoke | 0.56 (0.06) | 2.09E-19 | |
| Education | −0.08 (0.02) | 4.89E-05 | Exercise | −0.33 (0.09) | 1.93E-04 | |
| PCGrimAgeEAA | BMI | −0.02 (0.01) | 6.63E-03 | PWI | 0.002 (0.003) | 5.90E-01 |
| WHR | 1.33 (0.41) | 1.32E-03 | Drink | 0.14 (0.04) | 6.21E-04 | |
| Income | −0.07 (0.01) | 3.67E-07 | Smoke | 0.68 (0.04) | 6.25E-51 | |
| Education | −0.08 (0.01) | 2.84E-08 | Exercise | −0.22 (0.07) | 1.01E-03 | |
| PCPhenoAgeEAA | BMI | 0.01 (0.01) | 1.33E-01 | PWI | −0.002 (0.004) | 4.96E-01 |
| WHR | 1.23 (0.46) | 8.06E-03 | Drink | 0.02 (0.05) | 7.36E-01 | |
| Income | −0.07 (0.02) | 3.85E-05 | Smoke | 0.18 (0.05) | 6.63E-04 | |
| Education | −0.06 (0.02) | 3.89E-04 | Exercise | −0.25 (0.08) | 1.06E-03 | |
| ZhangY | BMI | −0.01 (0.01) | 2.54E-01 | PWI | 0.002 (0.002) | 3.20E-01 |
| WHR | 1.22 (0.31) | 7.82E-05 | Drink | 0.1 (0.03) | 8.29E-04 | |
| Income | −0.06 (0.01) | 4.60E-07 | Smoke | 0.42 (0.03) | 1.30E-34 | |
| Education | −0.04 (0.01) | 9.56E-05 | Exercise | −0.14 (0.05) | 5.86E-03 |
All regression models are adjusted for age, sex, and 10 principal components. All EAAs are scaled to mean = 0 and SD = 1. OR, Odds ratios; CI, confidence interval; SE, standard error; WHR, waist-hip ratio; Income, income level; Education, educational attainment; Exercise, regular exercise.