Table 1.
Clinicopathological characteristics of patients with HCC included in four cohorts.
| Characteristics | Cohort 1 | Cohort 2 | Surgical resection cohort |
Immunotherapy cohort |
p-value |
|---|---|---|---|---|---|
| No. of patients | 110 | 55 | 98 | 36 | |
| Age (years), median (range) | 52 (13–74) | 48 (22–76) | 54 (20–87) | 52 (31–70) | |
| Gender | |||||
| Female | 15 | 4 | 13 | 6 | 0.523 |
| Male | 95 | 51 | 85 | 30 | |
| HBsAg | |||||
| Negative | 13 | 7 | 15 | 6 | 0.829 |
| Positive | 97 | 48 | 83 | 30 | |
| AFP (ng/mL), median (range) | 267.85 (0–121,000) |
290.00 (0–121,000) |
213.10 (1–121,000) |
19,902.00 (4–121,000) |
|
| ALT (U/L), median (range) | 39.00 (0–118.0) |
34.00 (8.0–140.0) |
34.65 (11.0–389.3) |
49.2 (19.6–254.7) |
|
| Tumor size (cm), median (range) | 6.75 (1.5–17.0) |
7.0 (2.0–19.0) |
5.0 (1.5–30.0) |
11.2 (3.0–18.5) |
|
| Child–Pugh class | |||||
| A | 107 | 54 | 96 | 36 | 0.999 |
| B–C | 3 | 1 | 2 | 0 | |
| Tumor number | |||||
| Single | 74 | 40 | 80 | N.A. | 0.056 |
| Multiple | 36 | 15 | 18 | N.A. | |
| Vascular invasion | |||||
| No | 96 | 44 | 89 | 9 | < 0.0001* |
| Yes | 14 | 11 | 9 | 27 | |
| BCLC stage | |||||
| 0–A | 59 | 33 | 43 | 0 | < 0.0001* |
| B–C | 51 | 22 | 55 | 36 | |
HCC, hepatocellular carcinoma; HBsAg, hepatitis B surface antigen; AFP, α-fetoprotein; ALT, alanine aminotransferase; BCLC, Barcelona Clinic Liver Cancer; N.A., not applicable.
p-values were analyzed by Fisher’s exact test.