Figure 5.

Performance of models in prospective validation cohort

(A) Comparison of ROC curves for dual-/multimodality models in prospective validation cohort.

(B) Decision curve analysis demonstrating the clinical utility in predicting invasiveness of the five models in multimodal training cohort.

(C) Decision curve analysis demonstrating the clinical utility in predicting invasiveness of the five models in prospective validation cohort.

(D) Comparison of final pathology, intraoperative frozen section diagnosis and multi-RPC model predictive results in the prospective validation cohort. Dual-RC model, radiomics + clinical indicators dual-modality model; dual-PC model, pathology + clinical indicators dual-modality model; dual-RP model, radiomics + pathology dual-modality model; multi-RPC model, radiomics + pathology + clinical indicators multimodality model; AIS, adenocarcinoma in situ; MIA, minimally invasive adenocarcinoma; IA, invasive adenocarcinoma.