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. 2024 Nov 13;27(12):111340. doi: 10.1016/j.isci.2024.111340

Figure 1.

Figure 1

Tumor microenvironment is associated with immunotherapy efficacy in NSCLC

(A) The heatmap of the top 15 tumor and tumor microenvironment-associated signature values in responders (R) and non-responders (NR) in the NFH cohort.

(B) The volcano plot of differential expression gene analysis between responders (R) and non-responders (NR) in the NFH cohort. The red dots represent significantly upregulated genes (log2Fold Change >1, p-value <0.005), and the green dots represent significantly downregulated genes (log2Fold Change <−1, p-value <0.005). The represented genes in IKCscore were marked with a black circle.

(C) Unsupervised K-means clustering of selected immunotherapy efficacy-associated genes.

(D) Gene ontology enrichment analysis of genes in Immune pattern.

(E) Gene ontology enrichment analysis of genes in KRT pattern.

(F) A scatterplot demonstrated a positive correlation between the TumorPurity and KRTscore (Spearman test, r = 0.45, p = 0.00021).