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. 2024 Nov 13;27(12):111340. doi: 10.1016/j.isci.2024.111340

Figure 5.

Figure 5

IKCscore is associated with the immune-activated microenvironment

(A) CIBERSORT calculated the fraction of immune cells in the high and low IKCscore groups. The statistical difference between the two groups was compared through the Wilcoxon test. ∗, p < 0.05; ∗∗, p < 0.01; ns, not significant.

(B) Representative images of immunohistochemical stainings of CD3 and CD8 for resected tumor specimens in high IKCscore and low IKCscore.

(C) Alluvial diagram of high and low IKCscore groups with different TME subtypes (D, F, IE, and IE/F) and clinical response in GSE135222 cohort.

(D) The boxplot showed that IKCscore mainly increased in the IE subtype, while the lowest IKCscore was observed in the D subtype in the GSE135222 cohort (Kruskal−Wallis, p = 0.0016).

(E) The cell interaction network in high and low IKCscore groups.

(F) The volcano plot revealed the ligand-receptor pairs, transcription factors, and other factors related to IKCscore. IE, immune-enriched, non-fibrotic; IE/F, immune-enriched/fibrotic; F, fibrotic; D, immune-depleted.