Figure 7.

IB-DNQ alone or together with SOD1 inhibition suppresses tumor growth, metastasis, and tumor-initiating potential of TNBC xenografts. A–C, Vari068 mammary tumor xenograft mice were randomized and treated with vehicle or IB-DNQ as indicated in A. B and C, Mouse body weight was examined weekly for 4 weeks after treatment initiation (B) and mammary tumor growth following the last treatment was monitored for 2 weeks (C). *, P < 0.05 (n = 6). D, Lung histologic sections from each group of mice were harvested to examine metastatic tumor nodule formation. *, P < 0.05. E, staining of tumor sections treated with IB-DNQ vs. vehicle using antibodies against cleaved Casp3 or Ki67. F and H, SUM149 mammary tumor xenograft mice were randomized into four groups and treated with the regime indicated in F, and mouse body weight (G) and mammary tumor growth (H) were examined weekly for 6 weeks. ****, P < 0.0001 (vs. vehicle or IB-DNQ, n = 6). I, Tumor weight for each group of mice at the end of tumor monitoring. *, P < 0.05 (vehicle vs. combo, n = 6). C and H, Two-way ANOVA; D and I, two-tailed Student t test.