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Limiting-dilution transplantation in secondary SCID mouse.
| Cells injected | Tumors/injection sites | TIC frequency | P value (vs. vehicle) | ||
|---|---|---|---|---|---|
| 50,000 | 5,000 | 500 | |||
| Vehicle | 8/8 | 8/8 | 6/8 | 1/152 | |
| IB-DNQ | 8/8 | 8/8 | 2/8 | 1/546 | 0.055 |
| ATN224 | 8/8 | 5/8 | 3/8 | 1/1,586 | 0.0002 |
| Combination | 5/8 | 1/6 | 0/6 | 1/20,391 | 2.6e–15 |
