Cosinor-based rhythmometry analysis of circadian genes. Results are presented as relative expression compared to housekeeping genes. Figures include patients with active CS (red, n = 34) in remission (green, n = 10) against controls (grey, n = 34). Dots are single measurements for each time point. Curves are obtained from the pooled data. Genes included in the figure are: PER family (a, b, c), CLOCK (d), ARNTL (e), PRF1 (f) and TIMELESS (g). p values for comparisons of cosinor-based rhythmometry parameters are available in Table 2.