TABLE 3.
Prognostic factors associated with OS.
| Variable | Univariate analysis | Multivariate analysis | ||||||
|---|---|---|---|---|---|---|---|---|
| HR | Inf 95% CI | Sup 95% CI | p | HR | Inf 95% CI | Sup 95% CI | p | |
| B2M at diagnosis (> 3, ref: ≤ 3 mg/L) | 4.31 | 1.96 | 9.49 | 3e−04 | ||||
| Score TMTV (cutoff 510 cm3) + B2M—intermediate risk (ref: low risk) | 4.13 | 1.18 | 14.53 | 0.03 | 2.46 | 1.24 | 4.89 | 0.01 |
| Score TMTV (cutoff 510 cm3) + B2M—High risk (ref: low risk) | 7.03 | 1.90 | 26.04 | 0.003 | 4.13 | 1.96 | 8.73 | < 0.001 |
| SUVmax at diagnosis (> 12, ref: ≤ 12) | 1.32 | 0.6 | 2.92 | 0.5 | ||||
| Bone marrow invasion (Yes ref: No) | 1.07 | 0.47 | 2.42 | 0.9 | ||||
| PRIMA PI—intermediate (ref: Low) | 2.0 | 0.58 | 6.83 | 0.3 | ||||
| PRIMA PI—high (ref: Low) | 6.26 | 2.04 | 19.24 | 0.001 | ||||
| Hemoglobin at time of treatment (≥ 12, ref: < 12 g/dL) | 0.48 | 0.18 | 1.28 | 0.1 | ||||
| LDH at time of treatment (> ULN, ref: < ULN) | 1.10 | 0.38 | 3.23 | 0.9 | ||||
| Sex (M, ref: F) | 4.06 | 1.52 | 10.83 | 0.005 | 2.13 | 1.22 | 3.74 | 0.008 |
| FLIPI—intermediate (ref: Low) | 0.85 | 0.18 | 3.98 | 0.8 | ||||
| FLIPI—high (ref: Low) | 1.31 | 0.30 | 5.77 | 0.7 | ||||
Note: Values are bolded when they are considered statistically significant, meaning they are associated with a p‐value less than 0.05.
Abbreviations: B2M, beta‐2‐microglobulin; LDH, lactate dehydrogenase; TMTV, total metabolic tumor volume.