TABLE 2.
Univariate analysis of clinical factors and neuroinflammation‐related gene expressions in the discovery cohort.
| Variable | Group | Univariate analysis | |||
|---|---|---|---|---|---|
| n | 2 years OS, % | Median, years | p‐value | ||
| Clinical factors | |||||
| Age, years | ≤70 | 16 | 50 | 1.86 | 0.965 |
| >70 | 14 | 50 | 2.36 | ||
| KPS | <70 | 23 | 34.8 | 1.14 | 0.0362 |
| ≥70 | 7 | 100 | NA | ||
| Sex | Male | 19 | 52.6 | 2.62 | 0.518 |
| Female | 11 | 45.5 | 1.73 | ||
| LDH > upper limit | Low | 16 | 62.5 | 3.04 | 0.431 |
| High | 14 | 35.7 | 1.16 | ||
| Consciousness levels at diagnosis | No | 11 | 72.7 | 3.19 | 0.127 |
| Yes | 19 | 36.8 | 0.93 | ||
| Involvement of deep brain | No | 8 | 62.5 | 2.5 | 0.902 |
| Yes | 22 | 45.5 | 1.53 | ||
| Cell of origin | Non‐GCB | 24 | 50 | 1.86 | 0.353 |
| GCB | 6 | 50 | 1.73 | ||
| Gene expressions | |||||
| SOX10 | Low | 8 | 75 | 3.03 | 0.0438 |
| High | 22 | 40.9 | 0.89 | ||
| MOG | Low | 5 | 100 | NA | 0.0396 |
| High | 25 | 40 | 1.17 | ||
| MAG | Low | 7 | 85.7 | NA | 0.0248 |
| High | 23 | 39.1 | 1.17 | ||
| GJB1 | Low | 5 | 80 | NA | 0.0448 |
| High | 25 | 44 | 1.35 | ||
| MAL | Low | 8 | 75 | NA | 0.0438 |
| High | 22 | 40.9 | 1.26 | ||
| PLXNB3 | Low | 7 | 71.4 | NA | 0.0444 |
| High | 23 | 43.5 | 1.35 | ||
| S100B | Low | 8 | 68.2 | 3.03 | 0.00569 |
| High | 22 | 0 | 0.89 | ||
| PMP22 | Low | 8 | 75 | NA | 0.0462 |
| High | 22 | 40.9 | 1.26 | ||
| MYRF | Low | 13 | 69.2 | NA | 0.0311 |
| High | 17 | 35.2 | 1.17 | ||
| TMC7 | Low | 6 | 83.3 | NA | 0.0326 |
| High | 24 | 41.7 | 1.26 | ||
| PLEKHB1 | Low | 8 | 75 | NA | 0.0478 |
| High | 22 | 40.9 | 1.26 | ||
| SLC6A1 | Low | 5 | 60 | 2.99 | 0.0042 |
| High | 25 | 0 | 0.73 | ||
| MAPT | Low | 12 | 66.7 | 3.19 | 0.0112 |
| High | 18 | 25 | 1.03 | ||
| TUBB4A | Low | 8 | 63.6 | 3.03 | 0.00663 |
| High | 22 | 11.7 | 0.89 | ||
| GRM3 | Low | 8 | 59.1 | 2.83 | 0.0411 |
| High | 22 | 25 | 0.99 | ||
| ERBB3 | Low | 10 | 70 | NA | 0.0287 |
| High | 20 | 40 | 1.26 | ||
| NLGN2 | Low | 11 | 63.2 | 3.19 | 0.0183 |
| High | 19 | 27.3 | 1.14 | ||
| DST | Low | 12 | 66.7 | 3.03 | 0.0273 |
| High | 18 | 25 | 0.89 | ||
| GJA1 | Low | 11 | 63.2 | 2.99 | 0.0231 |
| High | 19 | 27.3 | 0.93 | ||
Abbreviation: KPS, Karnofsky performance status.