Table 1. Structures and Activities for Analogs 22–25^a.

^aCalcium mobilization assays in human mGlu₅-HEK293A cells were performed in the presence of an EC₈₀ fixed concentration of glutamate, n = 2 independent experiments in triplicate. The % Glu_Min is the measure of efficacy of the NAM to reduce an EC₈₀ response of glutamate.