Table 4. In Vivo Rat and Dog Pharmacokinetics of VU6043653.

IV PK
Species	Dose (mg/kg)	t1/2 (h)b	MRT (h)b	CLp (mL/min/kg)b	Vss (L/kg)b
Rat (SD)a	1.0	0.74	0.84	41	2.0
Dog (beagle)c	0.5	1.55	1.41	38	3.2

PO PK
Species	Dose (mg/kg)	Tmax (h)e	Cmax (ng/mL)e	AUC0-∞ (h·ng/mL)e	%Fe
Rat (SD)d	10.0	1.95	402	1320	43
Dog (beagle)f	3.0	0.67	70.3	264	20

^aMale Sprague–Dawley rats (n = 3); vehicle = 10% ethanol, 70% PEG400, 20% saline.

^bt_1/2 = terminal phase plasma half-life; MRT = mean residence time; V_ss = volume of distribution at steady-state; CL_p = plasma clearance.

^cMale beagle dogs (n = 3); vehicle = 10% ethanol, 70% PEG400, 20% saline.

^dMale Sprague–Dawley rats (n = 3); vehicle = 0.5% aqueous methylcellulose with 0.1% Tween 80.

^eT_max = time at which C_max occurs; C_max = maximum concentration; AUC = area under the curve; %F = oral bioavailability.

^fMale beagle dogs (n = 3); 0.5% aqueous methylcellulose with 0.1% Tween 80 in saline.