Table 3. Variation of the R² and R³ Substituents.

^aMeasured activity in the Nrf2 translocation assay in the engineered U2OS cell line.

^bMeasured activity in the ARE reporter assay in the HepG2 cell line.

^cReactivity against 10 equiv of glutathione in the presence of 20 equiv of TEA expressed as the time needed to reach 50% conversion.

^dPredicted Cl_blood in microsomes in mL min^–1 kg^–1.

^eApparent permeability (10^–6 cm/s) and efflux ratio measured in Caco-2 cells using 10 μM compound concentration.