Table 1.
All (n, %) | Training cohort (n, %) | Validation cohort (n, %) | p Value | |
---|---|---|---|---|
N | 192 | 123 | 69 | |
Age (mean, SD), years | 68.9 ± 12.1 | 69.0 ± 11.5 | 68.7 ± 13.4 | 0.54 |
Median (range) | 70 (63–78) | 70 (63–78) | 70 (64–79) | |
Age | 0.54 | |||
<60 | 35 (18.2) | 24 (19.5) | 11 (15.9) | |
⩾60 | 157 (81.8) | 99 (80.5) | 58 (84.1) | |
Gender | 0.47 | |||
Female | 79 (41.1) | 53 (43.1) | 26 (37.7) | |
Male | 113 (58.9) | 70 (56.9) | 43 (62.3) | |
ECOG | 0.14 | |||
0–1 | 154 (80.6) | 103 (83.7) | 51 (75.0) | |
⩾2 | 37 (19.4) | 20 (16.3) | 17 (25.0) | |
Renal function (mL/min) | 0.01 | |||
CCr ⩾ 60 | 66 (34.9) | 50 (41.7) | 16 (23.2) | |
CCr < 60 | 123 (65.1) | 70 (58.3) | 53 (76.8) | |
Primary site | 0.007 | |||
Bladder | 86 (44.8) | 64 (52.0) | 22 (31.9) | |
Upper tract | 104 (54.2) | 59 (48.0) | 45 (65.2) | |
Both | 2(1.0) | 0(0) | 2(2.9) | |
Visceral metastasis | 0.35 | |||
No | 91 (47.6) | 55 (45.1) | 36 (52.2) | |
Yes | 100 (52.4) | 67 (54.9) | 33 (47.8) | |
Lymph node metastasis | 0.96 | |||
No | 53 (27.7) | 34 (27.9) | 19 (27.5) | |
Yes | 138 (72.3) | 88 (72.1) | 50 (72.5) | |
Liver metastasis | 0.012 | |||
No | 150 (78.5) | 89 (73.0) | 61 (88.4) | |
Yes | 41 (21.5) | 33 (27.0) | 8 (11.6) | |
Lung metastasis | 0.27 | |||
No | 126 (66.0) | 77 (63.1) | 49 (71.0) | |
Yes | 65 (34.0) | 45 (36.9) | 20 (29.0) | |
Bone metastasis | 0.68 | |||
No | 152 (79.6) | 96 (78.7) | 56 (81.2) | |
Yes | 39 (20.4) | 26 (21.3) | 13 (18.8) | |
WBC (×103/μL) | 0.75 | |||
<10 | 139 (72.4) | 90 (73.2) | 49 (71.0) | |
⩾10 | 53 (27.6) | 33 (26.8) | 20 (29.0) | |
NLR | 0.81 | |||
<5 | 108 (56.3) | 70 (58.9) | 38 (55.1) | |
⩾5 | 84 (43.8) | 53 (43.1) | 31 (44.9) | |
Hemoglobin (g/dL) | 0.16 | |||
⩾10 | 121 (63.0) | 82 (66.7) | 39 (56.5) | |
<10 | 71 (37.0) | 41 (33.3) | 30 (43.5) | |
Bajorin prognostic factor | 0.90 | |||
0 | 73 (38.2) | 47 (38.2) | 26 (38.2) | |
1 | 98 (51.3) | 64 (52.0) | 34 (50.0) | |
2 | 20 (10.5) | 12 (9.8) | 8 (11.8) | |
PD-L1 (22C3) | 0.08 | |||
<10 | 72 (37.5) | 35 (28.5) | 37 (53.6) | |
⩾10 | 56 (29.2) | 36 (29.3) | 20 (29.0) | |
Missing | 64 (33.3) | 52 (42.3) | 12 (17.4) |
CCr, clearance of creatinine; ECOG, Eastern Cooperative Oncology Group; NLR, neutrophil-to-lymphocyte ratio; PD-L1, programmed cell death ligand-1; WBC, white blood cell count.