Fig. 2.

Methyl methanesulfonate contributes to enhanced PARGi sensitivity of ARH3 KO cells. (A-B) Representative images of colony formation assays carried out in control and ARH3 KO U2OS cells. As indicated, the cells were treated with or without 10 μM PARGi in combination with DMSO or genotoxins used at the indicated concentrations. (C) Representative images of colony formation assays carried out in control and ARH3 KO U2OS cells. As indicated, the cells were treated with or without PARGi in combination with DMSO or MMS or a combination of MMS and olaparib used at the indicated concentrations. Each experiment shown in this figure was conducted in biological and technical triplicates.