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Diagram illustrates the IFI16‐directed binding of the DDX5/PRC2/RNA complex to cccDNA chromatin. Downregulation of DDX5, or loss of the associated RNA disassembles the complex, relieving IFI16 binding and the epigenetic repression of cccDNA transcription. The significance of DNMT1 or HDAC1/2 co‐eluting with the DDX5/IFI16/PRC2 complex, as suggested by the data of Figure 2D, remains to be determined.
