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. 2024 Dec 2;102:skae365. doi: 10.1093/jas/skae365

Figure 1.

Figure 1.

Relative gene expression of steroidal implant receptors and growth signaling machinery from the muscle of steers receiving no steroidal implant (NoIMP) or a steroidal implant (TE200) and fed 0, 100, or 150 mg Zn/kg DM (Zn0, Zn100, Zn150, respectively). Samples were collected from the longissimus thoracis on day 11 and relative gene expression was calculated relative to NoIMP-Zn0 treatment. Contrast statements were formed to test the effect of increasing Zn from Zn0 to Zn150 within NoIMP (Zn-NoIMP) and TE200 (Zn-TE200), in addition to the main effect of steroidal implant (IMP; Zn0 and Zn150) and the linear effect of increasing Zn as Zn0, Zn100, and Zn150 within TE200 (Zn-L). A) Androgen receptor (AR), B) estrogen receptor (ESR1), and C) insulin-like growth factor-1 receptor (IGF1R) gene expression were not influenced by Zn or steroidal implant contrast statements (P ≥ 0.14). D) Epidermal growth factor receptor (EGFR) gene expression was greater for Zn150 than Zn0 steers administered TE200 (P = 0.03) and linearly increased with 0, 100, and 150 mg/kg DM of supplemental Zn within TE200 steers (P = 0.05). Steroidal implanted cattle (Zn0 and Zn150) had greater EGFR gene expression than NoIMP (P = 0.02). E) Matrix metalloproteinase 2 (MMP2) gene expression tended to be greater for Zn150 than Zn0 within TE200 (P = 0.10) and linearly increased with 0, 100, and 150 mg/kg DM of supplemental Zn for TE200 steers (P = 0.04). F) Phosphodiesterase 4B (PDE4B) gene expression tended to be greater for Zn150 than Zn0 within TE200 (P = 0.10) and linearly increased in TE200 steers with 0, 100, and 150 mg/kg DM of supplemental Zn (P = 0.03). Steroidal implanted cattle had lesser muscle PDE4B gene expression than NoIMP for Zn0 and Zn150 cattle (P = 0.02).