Extended Data Fig. 7. Distribution of core and variable synapses among neighborhoods.

a, Membrane contacts of the L4, adult and reference ${\mathbb{M}}^4$ datasets demonstrate that all three datasets have similar membrane contact profiles. For L4 and adult datasets, only bilaterally conserved contacts are included. b, Synaptic contacts on ${\mathbb{M}}^4$ membrane contacts broken down by degree of synaptic contact reproducibility (${\mathbb{C}}^1$, ${\mathbb{C}}^2$, ${\mathbb{C}}^3$ and ${\mathbb{C}}^4$). Most (56%) of conserved synapses (${\mathbb{C}}^4$) occur within clusters near the main diagonal, while variable synapses (${\mathbb{C}}^1$) are spread across clusters. c, Gap junction contacts on ${\mathbb{M}}^4$ membrane contacts broken down by degree of reproducibility (${\mathbb{G}}^1$, ${\mathbb{G}}^2$, ${\mathbb{G}}^3$ and ${\mathbb{G}}^4$). For all matrices: Row and column ordering is the same as the perturbed $\widetilde{{\mathbb{M}}^4}$ dataset (Extended Data Fig. 5i). Row and column colors correspond to final clusters assignments (Fig. 1c), where unclassified cells are colored gray. Matrix element ($i$, $j$) corresponds to the fraction of cell $i$’s membrane contact with cell $j$, with rows normalized to sum to 1.