Fig. 1.

A) Loadings of the PLS Inflammation Component 1; B) associations of PLS Inflammation Component 1 with neurobehavioral domain scores in adolescent participants of the ESPINA study. N = 508.

Analyses were conducted using PLS regression. Estimate is the difference in neurobehavioral score per unit increase in PLS composite 1). Models adjusted for age, gender, race, height-for-age z-score and parental education.

Attention and Inhibitory Control Residuals∼ (-0.023*std_CD14) + (0.061*std_CRP) + (0.01*std_IL_6) + (0.027*std_SAA) + (-0.07*std_sICAM_1) + (-0.084*std_sVCAM_1) + (-0.11*std_TNFα).

Language Residuals ∼ (-0.006*std_CD14) + (-0.057*std_CRP) + (-0.024*std_IL_6) + (-0.052*std_SAA) + (-0.062*std_sICAM_1) + (-0.065*std_sVCAM_1) + (-0.03*std_TNFα).

Memory Residuals ∼ (0.086*std_CD14) + (0.05*std_CRP) + (0.139*std_IL_6) + (0.054*std_SAA) + (0.062*std_sICAM_1) + (0.062*std_sVCAM_1) + (-0.016*std_TNFα).

Social Perception Residuals ∼ (-0.104*std_CD14) + (-0.075*std_CRP) + (0.012*std_IL_6) + (-0.065*std_SAA) + (-0.099*std_sICAM_1) + (-0.108*std_sVCAM_1) + (-0.126*std_TNFα).

Visuospatial Processing Residuals ∼ (-0.056*std_CD14) + (-0.064*std_CRP) + (0.011*std_IL_6) + (-0.055*std_SAA) + (-0.085*std_sICAM_1) + (-0.09*std_sVCAM_1) + (-0.073*std_TNFα).