Table 2.
Associations between inflammatory biomarker level and neurobehavioral performance in adolescents of the ESPINA study. N = 508.
| Neurobehavioral Domain |
|||||
|---|---|---|---|---|---|
| Attention & Inhibitory Control | Language | Memory & Learning | Visuospatial Processing | Social Perception | |
| sCD14 | 0.01 (-0.30, 0.32) | 0.06 (-0.23, 0.35) | 0.17 (-0.17, 0.50) | −0.22 (-0.52, 0.08) | −0.47 (-0.80, -0.13) |
| CRP | −0.01 (-0.06, 0.05) | 0.01 (-0.04, 0.06) | 0.03 (-0.03, 0.08) | −0.03 (-0.09, 0.02) | 0.00 (-0.06, 0.06) |
| IL-6 | −0.01 (-0.15, 0.13) | −0.12 (-0.24, 0.01) | −0.04 (-0.19, 0.12) | 0.00 (−0.16, 0.16) | −0.10 (-0.27, 0.07) |
| SAA | −0.01 (-0.06, 0.04) | −0.01 (-0.07, 0.05) | 0.02 (-0.04, 0.08) | −0.04 (-0.10, 0.02) | 0.01 (−0.06, 0.08) |
| sICAM-1 | −0.00 (−0.13, 0.12) | 0.01 (-0.12, 0.15) | 0.02 (−0.13, 0.17) | −0.06 (−0.21, 0.08) | −0.03 (-0.18, 0.12) |
| sVCAM-1 | −0.00 (-0.14, 0.13) | −0.03 (−0.17, 0.12) | −0.01 (−0.17, 0.14) | −0.08 (-0.24, 0.08) | −0.09 (-0.26, 0.07) |
| TNFα | 0.01 (-0.26, 0.28) | −0.10 (-0.38, 0.19) | −0.09 (−0.39, 0.20) | −0.09 (-0.44, 0.26) |
−0.42 (-0.72, -0.12) |
| Inflammation summary score | 0.00 (−0.07, 0.08) | 0.02 (−0.06, 0.09) | 0.04 (−0.04, 0.12) | −0.05 (−0.13, 0.02) |
−0.11 (-0.19, -0.03) |
Analyses were conducted using GEE models. Displayed values are score differences in NEPSY-II scores in relation to a 50% increase in inflammatory biomarker level (95% confidence interval), and were calculated by multiplying the coefficient by log(1.5).
Models adjusted for age, gender, race, height-for-age z-score, and parental education. Associations with Attention & Inhibitory Control were also adjusted for recent prior assessment in April 2016 (test-retest). Bolded text indicates statistical significance for the 95% confidence interval.