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. 2024 Dec 16;19(12):e0306514. doi: 10.1371/journal.pone.0306514

Fig 3. Identification and validation of overlapping genes with potential clinical diagnostic value for CHD.

Fig 3

(A) Venn diagram of six overlapping genes, namely IMP3, IFNG, CASP3, RNASEH2A, UMPS, and BATF, identified from the PPI networks generated by the three algorithms. (B) Bar graph, significant downregulation of these six genes in case groups compared to controls in the GSE42148 dataset. *p<0.05, **p<0.01, ***p<0.001. (C-H) ROC curve analysis of six genes (C) IFNG, (D) BATF, (E) CASP3, (F) IMP3, (G) RNASEH2A, and (H)UMPS, the horizontal axis is 1-Specificities, and the vertical axis is Sensitivities. The AUC value under the ROC curve is used to evaluate the performance of the model, and the closer to 1, the better the model performance.