Table 2.
Clinical molecular characteristics of high and low expression of 14-3-3ζ in HNSCC.
| Clinical features | Case(n=502) | Low expression (%) | High expression (%) | P value |
|---|---|---|---|---|
| T-stage | 0.8020 | |||
| T1 | 44 | 24 (4.78%) | 20 (3.98%) | |
| T2 | 144 | 72 (14.34%) | 72 (14.34%) | |
| T3 | 131 | 68 (13.55%) | 63 (12.55%) | |
| T4 | 183 | 87 (17.33%) | 96 (19.13%) | |
| N-stage | 0.6410 | |||
| N0 | 239 | 120 (23.9%) | 119 (23.71%) | |
| N1 | 96 | 46 (9.16%) | 50 (9.96%) | |
| N2 | 160 | 83 (16.53%) | 77 (15.34%) | |
| N3 | 7 | 2 (0.4%) | 5 (1%) | |
| M-stage | 0.2014 | |||
| M0 | 492 | 244 (48.61%) | 248 (49.4%) | |
| M1 | 10 | 7 (1.39%) | 3 (0.6%) | |
| Radiotherapy | 0.0127* | |||
| Yes | 187 | 80 (15.94%) | 107 (21.31%) | |
| No | 315 | 171 (34.06%) | 144 (28.69%) | |
| Histological grade | 0.0061** | |||
| G1 | 62 | 29 (5.78%) | 33 (6.56%) | |
| G2 | 310 | 141 (28.09%) | 169 (33.66%) | |
| G3 | 127 | 78 (15.54%) | 49 (9.77%) | |
| G4 | 3 | 3 (0.6%) | 0 (0%) | |
| Anatomical tumour subdivision | < 0.0001**** | |||
| Alveolar process | 18 | 12 (2.4%) | 6 (1.2%) | |
| Root of tongue | 23 | 13 (2.6%) | 10 (2%) | |
| Buccal mucosa | 22 | 9 (1.8%) | 13 (2.6%) | |
| Floor of mouth | 61 | 26 (5.2%) | 35 (7%) | |
| Palatum durum | 7 | 0 (0%) | 7 (1.4%) | |
| laryngopharynx | 10 | 5 (1%) | 5 (1%) | |
| throat | 111 | 54 (10.8%) | 57 (11.4%) | |
| lip | 3 | 2 (0.4%) | 1 (0.2%) | |
| Mouth cavity | 72 | 34 (6.8%) | 38 (7.6%) | |
| The tongue | 126 | 55 (11%) | 71 (14.1%) | |
| oropharynx | 9 | 6 (1.2%) | 3 (0.6%) | |
| tonsil | 40 | 35 (7%) | 5 (1%) |
(*p<0.05, **p<0.01, ****p<0.0001).