Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Nov 8;43(24):6573–6590. doi: 10.1038/s44318-024-00297-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the data associated with this article, unless otherwise stated in a credit line to the data, but does not extend to the graphical or creative elements of illustrations, charts, or figures. This waiver removes legal barriers to the re-use and mining of research data. According to standard scholarly practice, it is recommended to provide appropriate citation and attribution whenever technically possible.

PMC Copyright notice

(A) Domain architecture of the human mitochondrial RNase Z components. The N-terminal (NTD) and C-terminal (CTD) domains of ELAC2 are shown in dark and light purple, respectively. MBL1 and MBL2, which are the metallo-β-lactamase folds, and the exosite insertion are indicated with dotted lines. TRMT10C is shown in blue, with the NTD highlighted in cyan. MTS, mitochondrial targeting sequence. Unmodelled regions are in white. (B) The mt-tRNA precursor consists of tRNA^His (red) and tRNA^Ser(AGY) (gray line), of which the latter has been cleaved off in the ternary product structure. Base-paired nucleotides are in red circles, and non-base-paired ones are in white circles. The anticodon triplet is in gray circles. Canonical tRNA numbering is indicated (Giegé et al, 2012) and is used throughout the text (the correspondence with nucleotide numbers in mitochondrial tRNA^His, which was used in the PDB deposited structures, is shown in Appendix Table S1). (C, D) Composite cryo-EM density (C) and cartoon representation (D) of the RNase Z complex. Colored as in A. The four SDR5C1 subunits are shown in different shades of gray. The ELAC2 active site is marked with a yellow star.