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. 2024 Nov 8;43(24):6573–6590. doi: 10.1038/s44318-024-00297-w

Figure 3. Interaction of ELAC2 with the precursor mt-tRNAHis.

Figure 3

(A) Overview of the human mitochondrial RNase Z complex. The boxes represent the insets for (BE). (B) Contacts between the ELAC2 exosite, the T loop, and the TRMT10C N-terminal domain. (C) Contacts between the ELAC2 C-terminal helix, the TRMT10C, and the acceptor stem. (D) Recognition of the 5′-end of the mt-tRNA. Only the α-phosphate of G1 is shown since natural ELAC2 substrates carry a 5′-monophosphate. (E) Interaction of ELAC2 with the acceptor stem/T arm groove.