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. 2024 Nov 8;43(24):6573–6590. doi: 10.1038/s44318-024-00297-w

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the data associated with this article, unless otherwise stated in a credit line to the data, but does not extend to the graphical or creative elements of illustrations, charts, or figures. This waiver removes legal barriers to the re-use and mining of research data. According to standard scholarly practice, it is recommended to provide appropriate citation and attribution whenever technically possible.

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Figure EV1 — (A) ELAC2 activity in the presence and absence of the TRMT10C/SDR5C1 platform. (B) Cryo-EM density of particles containing two TRMT10C subunits. The 4xSDR5C1 platform offers two mt-tRNA/TRMT10C binding sites. The platform has a vertical and a horizontal twofold symmetry axis. Consequently, it supports two mt-tRNA/TRMT10C subcomplexes, which can be in two different but equivalent orientations (left and right panels). The 4xSDR5C1 are colored in different shades of gray; TRMT10C is colored in dark blue with the NTD highlighted in light blue; the mt-tRNA is in red. ELAC2 density is not visible due to the low occupancy. Source data are available online for this figure.