Table 1.
Concentration of growth factors in SCCO2 sterilized amniotic membrane
| Growth factor/receptor | Concentration (pg/mL ± SD) | Average fold increase above gamma irradiated | Average fold increase above e-beam irradiated |
|---|---|---|---|
| BDNF | 11.0 ± 1.0 | - | 12X |
| bFGF | 59.6 ± 5.0 | 60X | 60X |
| BMP-4 | 161.6 ± 20.0 | 162X | 162X |
| BMP-5 | 751.1 ± 120.0 | 17X | 2X |
| BMP-7 | 640.9 ± 143.0 | 26X | 11X |
| β-NGF | 40.5 ± 2.0 | 41X | 41X |
| EG-VEGF | 11.8 ± 2.0 | 4X | 12X |
| FGF-4 | 312.7 ± 163.0 | 313X | 10X |
| FGF-7 | 44.3 ± 8.0 | 5X | 2X |
| GDNF | 13.5 ± 3.0 | 14X | 6X |
| GH | 106.3 ± 36.0 | 106X | 106X |
| HB-EGF | 15.0 ± 3.0 | 15X | 15X |
| IGFBP-2 | 118.4 ± 9.0 | 2X | - |
| IGFBP-6 | 228.7 ± 105.0 | 229X | 6X |
| IGF-1 | 242.1 ± 87.0 | 2X | - |
| Insulin | 24.3 ± 2.0 | 24X | 24X |
| MCSF R | 43.9 ± 2.0 | 7X | 44X |
| NT-3 | 207.4 ± 11.0 | 207X | 207X |
| NT-4 | 31.1 ± 3.0 | 31X | 31X |
| PlGF | 5.9 ± 1.0 | 2X | 4X |
| SCF | 10.4 ± 2.0 | 10X | 10X |
| SCF-R | 31.0 ± 8.0 | 7X | 31X |
| TGF β1 | 15,422.5 ± 4245.0 | 7X | 2X |
| TGF β3 | 294.3 ± 12.0 | 294X | 294X |
| VEGF | 671.1 ± 47.0 | 88X | 2X |
| VEGF R2 | 36.2 ± 8.0 | 2X | - |
| VEGF R3 | 31.5 ± 3.0 | 32X | 32X |