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. 2024 Aug;17(4):524–536. doi: 10.1016/j.mucimm.2024.03.005

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© 2024 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 3 — Expression of chemokine receptors in eosinophils and interleukin-5 levels in patients was not altered by mepolizumab. (A, B) Comparison of the expression of chemokine receptors in eosinophils from different patient groups at protein level detected with flow cytometry in whole blood (A) or at transcriptional level (mIL5RA for membrane-bound IL-5RA, CCR3 for CCR3, and PTGDR2 for CRTH2) measured with qPCR in purified eosinophils (B). (C) Levels of IL-5 in sputum or serum from different asthma conditions and medical treatments determined with Luminex. (D) Effect of mepolizumab on serum IL-5 levels in paired samples. *p < 0.05, ***p < 0.001 and ****p < 0.0001. eos = eosinophilic; gMFI = geometric mean fluorescence intensity; IL = interleukin; IL-5RA = IL-5 receptor α-chain; mepo = mepolizumab; mRNA = messenger ribonucleic acid; OCS = oral corticosteroids; qPCR = quantitative polymerase chain reaction.