Table 6.

Mean ± standard deviation of the indexes of each alteration (INDEXalt) and individual indexes (INDEXind) observed in the liver of rats submitted to the dermal toxicity test with repeated dose.

Morphological change	(w)	Groups				p-value
		Control	T1 (26 µL/mL)	T2 (52 µL/mL)	T3 (104 µL/mL)
Increase in the number of Kupffer cells	1	0.00 ± 0.00a	0.00 ± 0.00a	0.20 ± 0.40a	0.80 ± 0.75a	0.063
Congestion in blood vessels	1	1.40 ± 0.45a	2.40 ± 0.49a	2.00 ± 0.63a	1.80 ± 0.75a	0.163
Dilation of the sinusoid lumen	1	0.00 ± 0.00a	0.40 ± 0.49a	0.80 ± 0.40a	1.20 ± 0.98a	0.039
INDEXind		1.40 ± 0.55a	2.80 ± 0.84ab	3.00 ± 1.22ab	3.80 ± 2.39b	0.028

Means followed by different lowercase letters in lines differ statistically (Kruskal-Wallis followed by Dunn post-hoc test; p < 0,05). (w) Importance factor.