Table 9.
Epidermal and dermal cells numerical density (x 10−3/µm2), thickness of the epidermis (µm) and percentage of collagen in the dermis (%) in rats submitted to the dermal toxicity test with repeated doses of acetylcarvacrol.
| Parameter |
Groups |
p-value | ||||
|---|---|---|---|---|---|---|
| Control | T1 (26 µL/mL) | T2 (52 µL/mL) | T3 (104 µL/mL) | |||
| Numerical density of the epidermal cells (x 10−3/µm2) | 6.35 ± 0.61a | 7.10 ± 1.08ab | 7.78 ± 0.61b | 8.20 ± 0.69b | 0.0088 | |
| Numerical density of the dermal cells (x 10−3/µm2) | 2.36 ± 0.26a | 3.38 ± 0.59ab | 3.95 ± 0.63b | 3.92 ± 0.75b | 0.0017 | |
| Thickness of the epidermis (µm) | 41.09 ± 10.41a | 69.99 ± 11.33ab | 81.20 ± 11.27bc | 111.18 ± 30.57c | 0.0002 | |
| Collagen (%) | 79.10 ± 1.73a | 78.00 ± 1.31a | 77.60 ± 3.93a | 77.94 ± 1.44a | 0.7680 | |
Means followed by different lowercase letters in lines differ statistically (one-way ANOVA followed by Tukey post-hoc test; p < 0,05).