Figure 1.

Overall study design

The microbiota profiles and clinical metadata from a Korean PIBD cohort and 11 published PIBD cohorts were analyzed to identify diagnostic biomarkers. A prognostic model was developed and tested based on the baseline samples with information on subsequent clinical responses. Multiple models were built, performance tested, and an ensemble model was created from the three top scoring models. The prognostic model was evaluated by 10-fold cross-validation and leave-one-study-out analysis. PIBD, pediatric inflammatory bowel disease.