Table 1. Mediation Effect of Geminocystis on PC via B-Cell Absolute Count in TBNK Panel.

Total effect β	Direct effect A β	Direct effect B β	Mediation effect β	Mediated proportion (%)
0.948	-0.803	-0.181	0.145	15.321

Total effect: The causal role of GM on PC. Direct effect A: The causal role of GM on immune cell traits. Direct effect B: The causal role of immune cell traits on PC. β(Indirect effect) = β(Direct effect A) × β(Direct effect B). The mediated proportion = β(indirect effect)/β(total effect). GM: gut microbiota; PC: pancreatic cancer.