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. 2024 Jul 4;2(4):274–289. doi: 10.1016/j.jaacop.2024.04.009

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© 2024 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Interaction Effects of Prenatal Drug Exposure and Childhood Trauma on Region of Interest (ROI) Activation in the Valence Condition

Note:(A) A double-hit specific decrease in the left inferior parietal lobule activity was revealed in the interaction models during the valence condition. Gray represents both unexplored and statistically non-significant regions. The coefficient describes the effect size and direction of the effect. (B) Whereas PDE+/CT+ was significantly associated with this effect, other subgroups were not. The dashed 0-line represents the PDE–/CT– reference group. (C) A double-hit specific increase in the right fusiform gyrus activity was revealed in the interaction models during the arousal condition. Gray represents both unexplored and statistically non-significant regions. The coefficient describes the effect size and direction of the effect. (D) Whereas PDE+/CT+ was significantly associated with this effect, other subgroups were not. The dashed 0-line represents the PDE–/CT– (reference) group. CT = childhood trauma; PDE = prenatal drug exposure.