Table 2.
Region of Interest (ROI) Linear Mixed Models
| Valence contrast | |||
|---|---|---|---|
| Main effects | |||
| ROI | CE | CI | pFDR |
| PDE+ | |||
| Superior frontal gyrus (L) | –0.077 | –0.13, –0.03 | .001 |
| Superior frontal gyrus (R) | –0.079 | –0.13, –0.03 | .037 |
| Fusiform (L) | –0.060 | –0.11, –0.01 | .027 |
| Fusiform (R) | –0.067 | –0.13, –0.01 | .025 |
| Insula (L) | –0.041 | –0.078, 0.00 | .035 |
| Insula (R) | –0.043 | –0.08, 0.00 | .036 |
| Rostral anterior cingulate cortex (L) | –0.074 | –0.014, –0.010 | .037 |
| Inferior parietal lobule (R) | –0.055 | –0.10, –0.01 | .017 |
| Hippocampus (R) | –0.044 | 0.03, 0.12 | .047 |
| CT+ | |||
| Amygdala (L) | 0.039 | 0.00, 0.08 | .046 |
| Interaction effects | |||
| PDE+/CT– | |||
| Superior frontal gyrus (L) | –0.073 | –0.13, –0.02 | .014 |
| Superior frontal gyrus (R) | –0.073 | –0.13, –0.01 | .014 |
| Fusiform (L) | –0.063 | –0.13, 0.00 | .05 |
| Fusiform (R) | –0.073 | –0.14, 0.00 | .043 |
| Isthmus cingulate cortex (R) | –0.068 | –0.13, 0.00 | .04 |
| Arousal contrast | |||
| Main effects | |||
| PDE+ | |||
| Fusiform (R) | 0.053 | 0.00, 0.10 | .045 |
| Interaction effects | |||
| PDE+/CT+ | |||
| Fusiform (R) | 0.103 | 0.01, 0.19 | .02 |
Note: Summary table of the observed significant activations for main effects (PDE and CT) and interaction effects (PDE/CT). CE = contrast estimate; CT = childhood trauma; PDE = prenatal drug exposure; pFDR = false discovery rate−corrected p value.