Figure 2.

Figure 2. Histopathological analysis. Oropharyngeal biopsy (A–C): Low- (A) and high- (B) power hematoxylin and eosin-stained sections demonstrate widespread ulceration (*) of the lining squamous epithelium (inset), hyalinized ectatic vessels, and reactive glioneuronal tissue (arrows indicate calcospherites). Glial fibrillary acidic protein (GFAP) confirms a dominant glial component (C). Resection of the intracranial mass (D-F) further substantiates the malformed nature of the glioneuronal tissue (D, arrows indicate calcospherites; inset highlights the disorganized arrangement of neurons by NeuN immunostaining), as well as, pigmented ocular epithelium (arrow, E) and unremarkable fragments of choroid plexus (F).