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Schematic representation of the effect of wild-type vaccine doses on BA.5 hybrid immunity, disease severity, and XBB reinfection risk. (A) Representation of virus-specific immune effectors and the clinical severity during acute SARS-CoV-2 infection across vaccine doses. (B) The immune response and reinfection risk 5 months following initial COVID-19 development across vaccine dose groups. Created with Biorender.com.
