Table 2.
Diagnostic characteristics of IENFD and CCM measurements for DSP and SFN.
| Variable | Distal symmetric polyneuropathy AUC (95% CI) | Small fiber neuropathy AUC (95% CI) |
|---|---|---|
| IENFD metrics | ||
| IENFD distal leg | 0.78 (0.68–0.89) | 0.85 (0.75–0.96) |
| IENFD proximal thigh | 0.59 (0.48–0.69) | 0.59 (0.46–0.73) |
| IENFD distal leg to proximal thigh ratio | 0.76 (0.65–0.87) | 0.82 (0.68–0.96) |
| Manual CCM | ||
| CNFD | 0.55 (0.42–0.68) | 0.55 (0.40–0.70) |
| CNBD | 0.58 (0.46–0.71) | 0.53 (0.39–0.67) |
| CNFL | 0.60 (0.48–0.72) | 0.59 (0.45–0.73) |
| TC | 0.56 (0.44–0.68) | 0.62 (0.48–0.76) |
| Automated CCM | ||
| CNFD | 0.57 (0.44,0.69) | 0.53 (0.39,0.68) |
| CNBD | 0.56 (0.43,0.68) | 0.50 (0.36,0.65) |
| CNFL | 0.60 (0.48,0.72) | 0.58 (0.43,0.72) |
| CTBD | 0.58 (0.45,0.70) | 0.53 (0.39,0.68) |
| CNFrD | 0.58 (0.45,0.70) | 0.45 (0.31,0.59) |
| CNFA | 0.58 (0.46,0.70) | 0.62 (0.48,0.75) |
| CNFW | 0.57 (0.44,0.69) | 0.57 (0.42,0.72) |
| Other neuropathy scales | ||
| MNSI questionnaire | 0.76 (0.68–0.85) | 0.81 (0.73–0.88) |
AUC, area under the receiver operating characteristics curve; CNBD, corneal nerve branch density; CNFA, corneal nerve fiber area; CNFD, corneal nerve fiber density; CNFL, corneal nerve fiber length; CNFrD, corneal nerve fractal dimension; CNFW, corneal nerve fiber width; CTBD, corneal total branch density; IENFD, intraepidermal nerve fiber density; MNSI, Michigan Neuropathy Screening Instrument; TC, tortuosity coefficient.