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. 2024 Oct 25;11(12):3175–3191. doi: 10.1002/acn3.52224

Figure 2.

Figure 2

Myotonia measures in adult DM1 and CDM participants correlate disparately with skeletal muscle spliceopathy. (A) Myotonia MDHI/CCMDHI scale average responses across CDM subcohorts and adult DM1 participants. Results are expressed as median ± 95% confidence interval (CI) via Kruskal–Wallis test with Dunn's multiple comparisons test. (B) Myotonia scale average value between DM1 individuals and all CDM individuals. Results are expressed as median ± 95% CI via unpaired Mann–Whitney test. (C) Correlation between [MBNL]inferred and vHOTthumb times in all DM1 individuals (left) and CDM individuals alone (right panel). Adult DM1 measures are removed from the statistical analysis in the right panel but grayed out and included in the figure for visual reference. (D) Correlation between CLCN1 exon 7a percent spliced in (PSI) and vHOTthumb times in all DM1 individuals and CDM individuals. All correlations are reported from a two‐tailed Spearman test.