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. 2024 Oct 25;11(12):3175–3191. doi: 10.1002/acn3.52224

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© 2024 The Author(s). Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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MBNL‐dependent mis‐splicing as measured by [MBNL]_inferred correlates moderately with motor function measures in DM1 individuals. Correlation between [MBNL]_inferred and (A) 9‐hole peg test (% predicted), (B) stair climbing speed (% predicted), (C) 6‐min walk distance (% predicted), and (D) walk/running speed (% predicted) in all DM1 individuals and CDM individuals. Left panels represent correlations of all DM1 subjects and right panels represent CDM subjects only. The adult DM1 measures were excluded from the CDM statistical analyses but grayed out and included in the figure on the right for visual reference. Correlations are reported from a two‐tailed Spearman test.