Figure 4.
Change in risk of incident cardiovascular diseases per SD increase in PGSMD among UK Biobank individuals with no diagnosis of psychiatric disorders and psychiatric medications. Associations for the sex-stratified cohorts (red: female; blue: male) were estimated with Cox proportional hazards regression models, including body mass index, smoking status, genotyping array, and 20 genetic PCs as covariates. The x axis shows the hazard ratio (HR) per SD increase in the polygenic score (PGS), with P values labeled, and error bars indicate 95% CIs. *A statistically significant difference in the log(HR) values between females and males (2-sided Wald test P<0.05). The dark gray line indicates an HR of 1. AF indicates atrial fibrillation; CAD, coronary artery disease; HF, heart failure; and MD, major depression.