Table 3.
Comparison of diagnostic efficacy of 3 assays in sputum and BALF specimens.
| Sputum specimen (n = 114) | BALF specimen (n = 47) | |||||||
|---|---|---|---|---|---|---|---|---|
| SAT-TB | Xpert MTB/RIF | Culture | SAT-TB + Xpert MTB/RIF | SAT-TB | Xpert MTB/RIF | Culture | SAT-TB + Xpert MTB/RIF | |
| AUC (95% CI) | 0.75 (0.66–0.83) | 0.81 (0.73–0.88) | 0.60 (0.51–0.69) | 0.84 (0.76–0.90) | 0.79 (0.64–0.89) | 0.86 (0.73–0.95) | 0.62 (0.47–0.76) | 0.87 (0.74–0.95) |
| Sensitivity (%) | 50.7 (39.0–62.2) | 62.3 (50.6–73.1) | 20.8 (12.4–31.5) | 67.5 (55.9–77.8) | 57.1 (34.0–78.2) | 76.2 (52.8–91.8) | 23.8 (8.2–47.2) | 76.2 (52.8–91.8) |
| Specificity (%) | 100.0 (90.5–100.0) | 100.0 (90.5–100.0) | 100.0 (90.5–100.0) | 100.0 (90.5–100.0) | 100.0 (86.8–100.0) | 96.2 (80.4–99.9) | 100.0 (86.8–100.0) | 96.2 (80.4–99.9) |
| PPV (%) | 100.0 (91.0–100.0) | 100.0 (92.6–100.0) | 100.0 (79.4–100.0) | 100.0 (93.2–100.0) | 100.0 (73.5–100.0) | 94.1 (69.7–99.1) | 100.0 (47.8–100.0) | 94.4 (71.1–99.2) |
| NPV (%) | 49.3 (43.7–55.0) | 56.1 (48.9–63.0) | 37.8 (35.1–40.5) | 59.7 (51.8–67.1) | 74.3 (63.8–82.6) | 83.9 (70.7–91.8) | 61.9 (56.1–67.4) | 86.2 (72.1–93.8) |
| Statistical value | 1.153 | 0.880 | ||||||
| P value | .249 | .379 | ||||||
AUC = the area under the curve, BALF = bronchoalveolar lavage fluid, NPV = negative predictive value, PPV = positive predictive value.