Wong 2003.

Methods	Randomised clinical trial Sequence generation: unclear. Allocation concealment: unclear. Blinding: adequate. Incomplete outcome data addressed: adequate. Free of selective reporting: inadequate. Free of other bias: unclear.
Participants	Country: China. Number randomised: 60. Post‐randomisation drop‐outs: 0. Mean age: 51.2 years. Females: 23 (38.3%). Major liver resections: not stated. Cirrhotic livers: 23 (38.3%). Inclusion criteria: Elective liver resection. Exclusion criteria Coronary artery disease. Congenital or acquired coagulation disorders other than liver cirrhosis. Serum sodium level < 130 mmol/l. NSAID or aspirin seven days of scheduled surgery. History of thrombovascular disorders or pulmonary thromboembolism.
Interventions	Participants were randomly assigned to two groups. Group 1: desmopressin (n = 30). Group 2: control (n = 30). Further details of intervention: single dose IV desmopressin 0.3 mcg/kg just after induction. Other details: Vascular occlusion: PTC in 17 and 18 patients in the two groups. Method of parenchymal transection: not stated. Management of raw surface: not stated. Other co‐interventions to decrease blood loss: none reported.
Outcomes	The outcome measures were transfusion requirements, operating time, and blood loss.
Notes	Attempts to contact the authors in November 2008 were unsuccessful.
Risk of bias
Bias	Authors' judgement	Support for judgement
Adequate sequence generation?	Unclear risk	Unclear.
Allocation concealment?	Unclear risk	Quote: "Patient randomization was by drawing a sealed envelope specifying a prescription for either desmopressin or placebo...." Comment: It is not clear whether the authors used opaque envelopes.
Blinding? All outcomes	Low risk	Quote: "Patient randomization was by drawing a sealed envelope specifying a prescription for either desmopressin or placebo, which was then prepared by an independent investigator and blinded to the patient, attending anesthesiologist and surgeon.
Incomplete outcome data addressed? All outcomes	Low risk	Comment: There were no post‐randomisation drop‐outs.
Free of selective reporting?	High risk	Comment: Important outcomes such as liver failure were not reported.
Free of baseline imbalance?	Unclear risk	Unclear.
Free of early stopping bias?	Unclear risk	Unclear.
Free of academic bias?	Low risk	Comment: There were no previously published trials of same comparisons by the author.
Free of sponsor bias?	Low risk	Quote: "This study was supported by a Hong Kong University CRCG grant (10202115/20013/20100/323/01)."