Table 2. Comparison of genome-wide SNP significance against local genetic correlation significance thresholds in all trait pairs and loci analysed.
All loci analysed showed sufficient local univariate heritability across compared traits to allow bivariate correlation analysis. Subsequent fine-mapping and colocalisation analyses were performed in this study for regions with at least a false discovery rate (FDR) adjusted significance for the local genetic correlation. SNP = single-nucleotide polymorphism.
| Number of traits in pair with genome-wide significant (p < 5 × 10−8) SNP in locus | Smallest significance threshold for local genetic correlation | |||
|---|---|---|---|---|
| Bonferroni (p < 8.26 × 10−5; 0.05/605) | FDR (pfdr < 0.05) | Nominal (p < 0.05) | Non-significant(p ≥ 0.05) | |
| 0 | 1 | 17 | 77 | 394 |
| 1 | 1 | 4 | 18 | 80 |
| 2 | 0 | 3 | 2 | 8 |