Fig. 9.

Polydatin ameliorates cerulein-induced AP in mice. (A to E) AP was induced by cerulein stimulation in mice. Mice were treated with indicated concentrations of polydatin (intragastric) or 10 mg/kg GA before cerulein stimulation. (A) Serum amylase and (B) lipase activities were determined to reflect pancreatic damage and disease severity. (C) The level of IL-1β in pancreas tissues was determined by ELISA. (D) Representative H&E staining of mouse pancreas and lung tissues. (E) Representative image of mouse pancreas and lung tissue sections for NLRP3 staining. Scale bar, 100 μm. Data are presented as mean ± SEM of 6 mice in each group. *P < 0.05, **P < 0.01 versus as indicated.