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. 2024 Jun 18;110(1):139–150. doi: 10.1210/clinem/dgae425

Table 3.

Problem behavior at 12 years after GH cessation or at around age 30 years

  Study group Comparison groups  
SGA-GH SGA-S SGA-CU AGA   All adults born SGA
mean (SD) mean (SD) mean (SD) mean (SD) P-value mean (SD)
Depressed/anxious 55.1 (7.2)a 56.4 (8.9)b 54.4 (6.6) 52.8 (5.4) .02 55.1 (7.4)d
Withdrawn 55.1 (6.1) 54.9 (7.1) 54.8 (6.4) 54.1 (5.4) .52 55.0 (6.4)
Somatic complaints 55.6 (7.7)a 55.8 (8.3)b 56.0 (7.0)c 52.8 (4.1) .01 55.8 (7.5)d
Thought problems 54.6 (6.3)a 54.2 (6.9) 53.0 (4.5) 52.8 (4.5) .15 53.9 (5.9)
Attention problems 55.5 (5.5)a 54.6 (5.8) 54.4 (4.5) 53.6 (4.5) .08 54.9 (5.3)
Aggressive behavior 52.8 (3.8) 52.8 (3.7) 52.7 (4.1) 52.2 (3.6) .28 52.8 (3.8)
Rule-breaking behavior 53.0 (3.7)a 51.8 (2.1) 52.3 (3.2) 51.7 (2.6) .20 52.5 (3.3)
Intrusive 52.1 (3.6) 52.0 (3.3) 51.6 (3.2) 51.4 (3.3) .22 51.9 (3.4)
Total scores
Internalizing problems 51.9 (10.7)a 53.2 (11.5)b 51.2 (11.1)c 47.5 (9.6) .01 51.9 (11.0)d
Externalizing problems 48.0 (8.3)a 48.1 (6.8) 47.2 (8.2) 44.9 (8.5) .07 47.7 (7.9)
Total problems 48.7 (9.9)a 49.5 (8.8)b 48.1 (8.2) 45.3 (8.8) .047 48.6 (9.1)d

The Adolescent Behavior Check List questionnaire was completed by subjects 12 years after GH cessation. Scores are presented as mean (SD). Lower scores indicate less problem behavior. Bold P-values are considered significant differences between groups.

Abbreviations: AGA, appropriate for gestational age with normal height; SGA, small for gestational age; SGA-CU, small for gestational age with spontaneous catch-up growth to normal height; SGA-S, small for gestational age with short stature.

a P < .05 between SGA-GH adults and AGA adults.

b P < .05 between SGA-S adults and AGA adults.

c P < .05 between SGA-CU adults and AGA adults.

d P < .05 between all adults born SGA and AGA adults.