Table 3. The probes showing potential pleiotropic association with EC in the SMR analysis*.

Probe	Gene	CHR	Top SNP	PeQTL	PGWAS	Beta	SE	PSMR	PHEIDI	Q value
ILMN_1751400	SKAP1	17	rs2938483	3.32×10−68	1.49×10−8	−0.185	0.034	7.19×10−8	1.25×10−5	0.0006
ILMN_2369018	EVI2A	17	rs7505	2.26×10−151	1.85×10−6	0.102	0.022	2.70×10−6	0.379	0.012
ILMN_1809347	SRP14	15	rs17722526	1.41×10−13	2.46×10−8	−0.410	0.092	8.49×10−6	0.225	0.023
ILMN_1733579	EVI2A	17	rs2525570	3.63×10−58	4.80×10−6	−0.161	0.037	1.09×10−5	0.425	0.023
ILMN_1683950	SNX11	17	rs62064953	2.15×10−77	1.05×10−5	0.140	0.033	1.80×10−5	2.49×10−6	0.031
ILMN_1696051	SNX11	17	rs12949879	3.09×10−49	1.17×10−5	0.179	0.043	2.65×10−5	5.61×10−5	0.038

*, the GWAS summarized data can be downloaded at https://www.ebi.ac.uk/gwas/studies/GCST006464. The CAGE eQTL data can be downloaded at https://cnsgenomics.com/data/SMR/#eQTLsummarydata. P_eQTL is the P value of the top associated cis-eQTL in the eQTL analysis, and P_GWAS is the P value for the top associated cis-eQTL in the GWAS analysis. Beta is the estimated effect size in SMR analysis, SE is the corresponding standard error, P_SMR is the P-value for SMR analysis and P_HEIDI is the P value for the HEIDI test. Q-value is the adjusted P value using FDR. CAGE, Consortium for the Architecture of Gene Expression; CHR, chromosome; EC, endometrial cancer; eQTL, expression quantitative trait loci; FDR, false discovery rate; GWAS, genome-wide association study; HEIDI, heterogeneity in dependent instruments; SE, standard error; SMR, summary data-based Mendelian randomization; SNP, single-nucleotide polymorphism.