Figure 8.

AIM2-related immune regulatory signaling pathway. To enhance understandings of the molecular signaling pathways associated with AIM2-mediated immune infiltration in AML, we first screened AIM2-related differentially expressed genes using the TCGA database, and then conducted a GSEA to investigate signal pathway enrichment. SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; NF, nuclear factor; KEGG, Kyoto Encyclopedia of Genes and Genomes; BCR, B-cell receptor; IL, interleukin; NES, normalized effect size; PID, primary immunodeficiency; Th, T helper; MHC, major histocompatibility complex; AIM2, absent in melanoma 2; AML, acute myeloid leukemia; TCGA, The Cancer Genome Atlas; GSEA, gene set enrichment analysis.